The Health Status of African Americans in Allegheny County-A Black Paper for the Urban League of Pittsburgh

This report examines the health conditions of African Americans in Allegheny County (hereafter referred to as “the County”). It documents the leading causes of death of black men and women, infant mortality, rates of firearm injuries and fatalities, and rates of sexually transmitted diseases (STDs). The data reported serves to benchmark the current health status of African Americans and, by way of comparison, whites in the County. It is an important initial step towards achieving the Healthy People 2010 goal of eliminating racial/ethnic health status disparities in the County

To germinate or not to germinate: more than just a question of dormancy

Consider the following four quotations concerning the distinction between breaking dormancy and stimulating germination

Nouns and Academic Interactions: A Neglected Feature of Metadiscourse

Metadiscourse has received considerable attention in recent years as a way of understanding the rhetorical negotiations involved in academic writing. But while a useful tool in revealing something of the dynamic interactions which underlie persuasive claim making, it has little to say about the role of nouns in this process. We address this gap by exploring the rhetorical functions of what we call metadiscursive nouns (such as fact, analysis, belief) and by mapping them onto a model of metadiscourse. The study examines ‘metadiscursive noun + post-nominal clause’ patterns, one of the most frequent structures containing such nouns, in a corpus of 120 research articles across six disciplines. Developing a rhetorically based classification and exploring the interactive and interactional use of metadiscursive nouns, we show that they are another key element of metadiscourse, offering writers a way of organizing discourse into a cohesive flow of information and of constructing a stance towards it. These interactions are further shown to realize the epistemological assumptions and rhetorical practices of particular disciplines

Sense about science - making sense of crime

Booklet 'Making Sense of Crime' published by registered charity 'Sense About Science'There’s always heated debate about crime in the media and a lot of political argument about how we should respond to it. But these arguments rarely provide insight into what actually causes crime, what lies behind trends over time and in different places, and how best to go about reducing it. Values inform how a society decides to deal with crime. We may decide that rehabilitation is a better principle than punishment, and this will influence how we decide what is most effective. However, we also expect these choices to be disciplined by sound evidence, because if crime policy ignores what works and what doesn’t, there are likely to be bad social consequences. And with over £10bn spent annually on tackling crime through the police, prisons, probation and courts, unless we look at evidence we can’t see how effective any of it is. Crime policy usually has twin aims – to prevent crime, and to seek justice by punishing those who commit offences. Research shows there’s only a loose link, if any, between the way offenders are punished and the number of offences committed. There is no reliable evidence for example, that capital punishment reduces serious crimes as its supporters claim. Yet politicians and commentators regularly claim that more punishments are a way to cut crime. Academic, government and community organisations have all said crime policies need to be based more on evidence, but much of the evidence available at the moment is poor or unclear. Debates about crime rarely reflect how strong the evidence behind opposing policies is, and even when politicians honestly believe they’re following the evidence, they tend to select evidence that supports their political views. This guide looks at some of the key things we do know and why it has been so difficult to make sense of crime policy. An important point throughout is that policymakers sometimes have to make decisions when things are not clear-cut. They have a better chance of making effective policies if they admit to this uncertainty – and conduct robust research to find out more. In the following pages we have shared insights from experts in violent crime, policing, crime science, psychology and the media’s influence on the crime debate. They don’t have all the answers, but we hope they leave you better-placed to hold policymakers and commentators to account and promote a more useful discussion about crime

The Formation and Stability of DC-SIGN Microdomains Require its Extracellular Moiety: DC-SIGN Microdomains Require Extracellular Moiety

DC-SIGN (Dendritic cell-specific ICAM-3-grabbing non-integrin) is a Ca2+-dependent transmembrane lectin that binds a large variety of pathogens and facilitates their uptake for subsequent antigen presentation. This receptor is present in cell surface microdomains, but factors involved in microdomain formation and their exceptional stability are not clear. To determine which domain/motif of DC-SIGN facilitates its presence in microdomains, we studied mutations at key locations including truncation of the cytoplasmic tail, and ectodomain mutations that resulted in removal of the N-linked glycosylation site, the tandem repeats and the carbohydrate recognition domain (CRD) as well as modification of the calcium sites in the CRD required for carbohydrate binding. Confocal imaging and FRAP measurements showed that the cytoplasmic domain and N-linked glycosylation site do not affect the ability of DC-SIGN to form stable microdomains. However, truncation of the CRD results in complete loss of visible microdomains and subsequent lateral diffusion of the mutants. Apart from cell adhesions, membrane domains are thought to be localized primarily via the cytoskeleton. By contrast, we propose that interactions between the CRD of DC-SIGN and the extracellular matrix and/or cis interactions with transmembrane scaffolding protein(s) play an essential role in organizing these microdomains

West Nile Virus as a Cause of Death Among Endangered Eastern Loggerhead Shrikes, Lanius ludovicianus migrans, in West St. Paul, Manitoba

In July 2006, three Eastern Loggerhead Shrike (Lanius ludovicianus migrans) nestlings were found dead in a nest in West St. Paul, near Winnipeg, Manitoba. The Eastern Loggerhead Shrike is an endangered form in Canada and populations are in decline. Reverse transcription-polymerase chain reaction and immunohistochemical staining detected West Nile virus in the tissues of the nestlings indicating the cause of death. This is the first confirmed report of West Nile virus in wild populations of Eastern Loggerhead Shrikes in North America. These findings will challenge conservation biologists in their efforts to develop recovery and management plans for the endangered Eastern Loggerhead Shrike, as well as in the implementation of captive rearing programs

Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy

Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of less than 8%. In an attempt to improve this, epigenetic modifying agents have been combined as therapies in clinical studies. In particular combinations with Decitabine and Vorinostat have had varying degrees of efficacy. This study therefore aimed to understand the underlying molecular mechanisms of these agents to identify potential rational epi-sensitized combinations. Combined Decitabine-Vorinostat treatment synergistically decreased cell proliferation, induced apoptosis, enhanced acetylation of histones and further decreased DNMT1 protein with HL-60 cells showing a greater sensitivity to the combined treatment than OCI-AML3. Combination therapy led to reprogramming of unique target genes including AXL, a receptor tyrosine kinase associated with cell survival and a poor prognosis in AML, which was significantly upregulated following treatment. Therefore targeting AXL following epi-sensitization with Decitabine and Vorinostat may be a suitable triple combination. To test this, cells were treated with a novel triple combination therapy including BGB324, an AXL specific inhibitor. Triple combination increased the sensitivity of OCI-AML3 cells to Decitabine and Vorinostat as shown through viability assays and significantly extended the survival of mice transplanted with pretreated OCI-AML3 cells, while bioluminescence imaging showed the decrease in disease burden following triple combination treatment. Further investigation is required to optimize this triple combination, however, these results suggest that AXL is a potential marker of response to Decitabine-Vorinostat combination treatment and offers a new avenue of epigenetic combination therapies for acute myeloid leukemia

Regular Expression Matching and Operational Semantics

Many programming languages and tools, ranging from grep to the Java String library, contain regular expression matchers. Rather than first translating a regular expression into a deterministic finite automaton, such implementations typically match the regular expression on the fly. Thus they can be seen as virtual machines interpreting the regular expression much as if it were a program with some non-deterministic constructs such as the Kleene star. We formalize this implementation technique for regular expression matching using operational semantics. Specifically, we derive a series of abstract machines, moving from the abstract definition of matching to increasingly realistic machines. First a continuation is added to the operational semantics to describe what remains to be matched after the current expression. Next, we represent the expression as a data structure using pointers, which enables redundant searches to be eliminated via testing for pointer equality. From there, we arrive both at Thompson's lockstep construction and a machine that performs some operations in parallel, suitable for implementation on a large number of cores, such as a GPU. We formalize the parallel machine using process algebra and report some preliminary experiments with an implementation on a graphics processor using CUDA.Comment: In Proceedings SOS 2011, arXiv:1108.279